This talking Meowth is based off of the Team Rocket Meowth in the anime. As a part of Jessie and James's trio, Meowth is saddened by their brainwashing at the hands of Mewthree. Appointed by Giovanni, Meowth leads the war's Human to Pokémon Communications.
After Joey gets abducted by a Haunter, Meowth appears to permit the Player access through the Ghost Pokémon barrier around Saffron City. During Sabrina's assault on the city, Meowth acts as the target that must be defended.